Commentary: Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Authors

  • Morgan Riggan Division of Medical Toxicology, Ronald O Perelman Department of Emergency Medicine, New York University School of Medicine
  • Robert Hoffman Division of Medical Toxicology, Ronald O Perelman Department of Emergency Medicine, New York University School of Medicine
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Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...

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comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

objective(s): comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (amt) on activated charcoal (ac) and sodium polystyrene sulfonate (sps). ac has been long used as gastric decontamination agent for tricyclic antidepressants and sps has showed to be highly effective on in-vitro drugs adsorption. materials and methods: sprague-dawley male rats...

full text

Comparison of activated charcoal and sodium polystyrene sulfonate resin efficiency on reduction of amitriptyline oral absorption in rat as treatments for overdose and toxicities

OBJECTIVES Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. MATERIALS AND METHODS Sprague-Dawley male rats w...

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Journal title

volume 20  issue 5

pages  457- 457

publication date 2017-05-01

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